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Supercritical fluid chromatography is a type of normal-phase chromatography in which the mobile phase is a supercritical fluid, having the properties of both a gas and a liquid.
SFC is often used for chiral separations, but the growing range of stationary phases available is extending its reach to achiral separations, for both sample prep and analysis.
A typical SFC system includes a CO2 pump, injector, oven, column, detector, and recorder. Since the chromatographic flow path must be pressurized, a backpressure regulator is also required.
SFC can be used to analyze many materials, including:
Systems are available that feature easy switching for use with HPLC applications.
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