Are Sweeteners as Natural as We Think? – Chromatography Investigates

A team from the University of Bonn in Germany has found that compounds known as steviol glycosides are unchanged during different stages of production. The report helps to confirm that the sweetener or sugar substitute known as stevia can be considered as a natural sweetener. Scientists analysed three different batches of stevia throughout the production [Read More...]

Behind The Scenes Of A Las Vegas Marijuana Testing Lab

The space is no bigger than a good-sized office break room. On beige counters along the walls and on an island in the center sit off-white rectangular boxes that could be copiers or printers. But the several hundred thousand dollars of highly sensitive scientific equipment in this room — and others like it — will be [Read More...]

Optimization of Chromatography in the Lab

While analytical laboratories may still rely to some extent on trial-and-error approaches, there is agreement that this is increasingly less effective as systems become more complex. Regulatory bodies are putting increasing pressure on pharmaceutical companies to incorporate Quality by Design (QbD) approaches throughout the drug development process. QbD is defined in the ICH Q8 guideline [Read More...]

The Future of Clinical Mass Spectrometry

As a mass spectrometrist who has migrated into the realm of clinical chemistry, I frequently tell my clinical chemistry colleagues that mass spectrometrists want to take over the world. Although an exaggeration, this statement is seldom challenged, probably in recognition of the many positive ways that mass spectrometry already has influenced the clinical laboratory and [Read More...]

Heated Dispute Over Analytical Method

Study finds that GC-MS changes or destroys sample compounds DEGRADING EXPERIENCE LC-MS peaks from analyses of a small-molecule sample maintained at room temperature (bottom) and heated for five minutes at 250 °C (top) differ considerably. If you’ve used gas chromatography-mass spectrometry (GC-MS) to analyze unknown compounds from cells and biological tissue, a new [Read More...]

Mixing Water and Gas: The Quantitative Measurement of Water by Gas Chromatography Using Ionic Liquid Capillary Columns

The determination of water content in solvents, alcoholic beverages and various consumer products such as foods, pharmaceuticals, fuels, and petroleum products is one of the most common types of chemical testing. Many techniques such as gravimetric analysis, Karl Fischer Titration, near infra-red spectroscopy, gas chromatography (GC) and others have been used for water quantification with [Read More...]

Multi-Residue Analysis By Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Multi-Residue Analysis of 90 Emerging Contaminants In Liquid And Solid Environmental Matrices By Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry   Abstract Reported herein is new analytical methodology for the determination of 90 emerging contaminants (ECs) in liquid environmental matrices (crude wastewater, final effluent and river water). The application of a novel buffer, ammonium fluoride improved [Read More...]

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