Water of life Cheminformatics can be used to process data from headspace mass-spectrometry (HS-MS), mid-infrared (MIR) and UV–Vis spectroscopy and so ascertain the authenticity and origin of Irish, Spanish, Bourbon, Tennessee Whisky and Scotch, according to a study published by researchers from Poland and Spain. Their approach is quick and simple and requires no pre-preparation [Read More...]
A new mass spectrometry imaging protocol allows the analysis of metabolites like adenosine monophosphate from formalin-fixed paraffin-embedded (FFPE) tissue, shown here as background. (Credit: Helmholtz Zentrum München) The metabolic composition of tissues can be determined—in one day—in fixed-tissue samples, using a newly developed mass spectrometry imaging protocol. Using relatively small amounts of material, [Read More...]
While analytical laboratories may still rely to some extent on trial-and-error approaches, there is agreement that this is increasingly less effective as systems become more complex. Regulatory bodies are putting increasing pressure on pharmaceutical companies to incorporate Quality by Design (QbD) approaches throughout the drug development process. QbD is defined in the ICH Q8 guideline [Read More...]
With a price tag of $1 million, many schools can't afford the latest spectrometry equipment to help students conduct experiments, like determining the composition of a polymer or detecting the presence of cocaine in a hair sample. But that may soon change, thanks to the first virtual mass spectrometry system—an interactive, Web-based educational device developed [Read More...]
As a mass spectrometrist who has migrated into the realm of clinical chemistry, I frequently tell my clinical chemistry colleagues that mass spectrometrists want to take over the world. Although an exaggeration, this statement is seldom challenged, probably in recognition of the many positive ways that mass spectrometry already has influenced the clinical laboratory and [Read More...]
Study finds that GC-MS changes or destroys sample compounds DEGRADING EXPERIENCE LC-MS peaks from analyses of a small-molecule sample maintained at room temperature (bottom) and heated for five minutes at 250 °C (top) differ considerably. If you’ve used gas chromatography-mass spectrometry (GC-MS) to analyze unknown compounds from cells and biological tissue, a new [Read More...]
A new universal petrochemical analyzer combines the speed of ballistic gas chromatography (GC) with the ability of high-pressure mass spectrometry (HPMS) technology to identity molecules at lower limits. Officials with Boston-based 908 Devices Inc. are seeking to “democratize” chemical analysis with mass spectrometry by freeing it from its Achilles heel, the complex vacuum pumping system. [Read More...]
Multi-Residue Analysis of 90 Emerging Contaminants In Liquid And Solid Environmental Matrices By Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry Abstract Reported herein is new analytical methodology for the determination of 90 emerging contaminants (ECs) in liquid environmental matrices (crude wastewater, final effluent and river water). The application of a novel buffer, ammonium fluoride improved [Read More...]
