Fraction Trapping Liquid Chromatography (FTLC)

Fraction Trapping Liquid Chromatography (FTLC)

The Fraction Trapping Liquid Chromatography (FTLC) System is unlike any other product on the market today. The FTLC System is ideally suited for processing fractions greater than 25 mL volume and sample masses up to 500 mg that have been purified on virtually any preparative HPLC system. The collected fractions are re-processed on the FTLC System. While the compounds are trapped on the column, the water content passes through to waste. Washing steps can also be performed for removal of salts, buffers and mobile phase modifiers such as TFA, which can hinder further LC/MS analysis. Fractions containing greater than 50% water content can be processed and collected in 100% organic solvent. This allows for fast dry-down times at lower temperatures for samples that are heat-sensitive, thereby eliminating degradation. Dry-down times of 12–24 hours can be reduced to less than 30 minutes.

  • Completely remove water content
  • Reduces dry-down from hours to minutes
  • Removes buffers, modifiers and salts
  • Process fractions in 12 to 18 minutes
  • Load up to 500 mg
  • Optional breakthrough detector and secondary fraction collector

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